Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II

Complex formation between hexokinase-II (HKII) and the mitochondrial VDAC1 is crucial to cell growth and survival. We hypothesize that HKII first inserts into the outer membrane of mitochondria (OMM) and then interacts with VDAC1 on the cytosolic leaflet of OMM to form a binary complex. To systemati...

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Vydáno v:Commun Biol
Hlavní autoři: Haloi, Nandan, Wen, Po-Chao, Cheng, Qunli, Yang, Meiying, Natarajan, Gayathri, Camara, Amadou K. S., Kwok, Wai-Meng, Tajkhorshid, Emad
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8175357/
https://ncbi.nlm.nih.gov/pubmed/34083717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02205-y
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