Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II

Complex formation between hexokinase-II (HKII) and the mitochondrial VDAC1 is crucial to cell growth and survival. We hypothesize that HKII first inserts into the outer membrane of mitochondria (OMM) and then interacts with VDAC1 on the cytosolic leaflet of OMM to form a binary complex. To systemati...

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Detalhes bibliográficos
Publicado no:Commun Biol
Main Authors: Haloi, Nandan, Wen, Po-Chao, Cheng, Qunli, Yang, Meiying, Natarajan, Gayathri, Camara, Amadou K. S., Kwok, Wai-Meng, Tajkhorshid, Emad
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8175357/
https://ncbi.nlm.nih.gov/pubmed/34083717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02205-y
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