Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations

Mosaic inactivation of CCM2 in humans causes cerebral cavernous malformations (CCMs) containing adjacent dilated blood-filled multi-cavernous lesions. We used CRISPR-Cas9 mutagenesis to induce mosaic inactivation of zebrafish ccm2 resulting in a novel lethal multi-cavernous lesion in the embryonic c...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Li, Wenqing, Tran, Virginia, Shaked, Iftach, Xue, Belinda, Moore, Thomas, Lightle, Rhonda, Kleinfeld, David, Awad, Issam A, Ginsberg, Mark H
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8175082/
https://ncbi.nlm.nih.gov/pubmed/34013885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.62155
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