Kallikrein‐1 Blockade Inhibits Aortic Expansion in a Mouse Model and Reduces Prostaglandin E2 Secretion From Human Aortic Aneurysm Explants

BACKGROUND: Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. The kinin B2 receptor agonist, bradykinin, has been implicated in AAA pathogenesis through promoting inflammation. Bradykinin is generated from high‐ and low‐molecular‐weight kininogen by the serine prote...

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Vydáno v:J Am Heart Assoc
Hlavní autoři: Moran, Corey S., Biros, Erik, Krishna, Smriti M., Morton, Susan K., Sexton, Daniel J., Golledge, Jonathan
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2021
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8174241/
https://ncbi.nlm.nih.gov/pubmed/33599139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.120.019372
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