Kallikrein‐1 Blockade Inhibits Aortic Expansion in a Mouse Model and Reduces Prostaglandin E2 Secretion From Human Aortic Aneurysm Explants

BACKGROUND: Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. The kinin B2 receptor agonist, bradykinin, has been implicated in AAA pathogenesis through promoting inflammation. Bradykinin is generated from high‐ and low‐molecular‐weight kininogen by the serine prote...

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Detaylı Bibliyografya
Yayımlandı:J Am Heart Assoc
Asıl Yazarlar: Moran, Corey S., Biros, Erik, Krishna, Smriti M., Morton, Susan K., Sexton, Daniel J., Golledge, Jonathan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2021
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8174241/
https://ncbi.nlm.nih.gov/pubmed/33599139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.120.019372
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