Kallikrein‐1 Blockade Inhibits Aortic Expansion in a Mouse Model and Reduces Prostaglandin E2 Secretion From Human Aortic Aneurysm Explants

BACKGROUND: Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. The kinin B2 receptor agonist, bradykinin, has been implicated in AAA pathogenesis through promoting inflammation. Bradykinin is generated from high‐ and low‐molecular‐weight kininogen by the serine prote...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Moran, Corey S., Biros, Erik, Krishna, Smriti M., Morton, Susan K., Sexton, Daniel J., Golledge, Jonathan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8174241/
https://ncbi.nlm.nih.gov/pubmed/33599139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.120.019372
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