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Long‐Term Dipeptidyl Peptidase 4 Inhibition Worsens Hypertension and Renal and Cardiac Abnormalities in Obese Spontaneously Hypertensive Heart Failure Rats

BACKGROUND: The long‐term effects of dipeptidyl peptidase 4 (DPP4) inhibitors on blood pressure and cardiovascular and renal health remain controversial. Herein, we investigated the extended (>182 days) effects of DPP4 inhibition in a model of spontaneous hypertension, heart failure, diabetes mel...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Jackson, Edwin K., Mi, Zaichuan, Gillespie, Delbert G., Cheng, Dongmei, Tofovic, Stevan P.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8174220/
https://ncbi.nlm.nih.gov/pubmed/33682436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.120.020088
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