SARM1 is a Metabolic Sensor Activated by an Increased NMN/NAD(+) Ratio to Trigger Axon Degeneration

Axon degeneration is a central pathological feature of many neurodegenerative diseases. SARM1 is an NAD(+)-cleaving enzyme whose activation triggers axon destruction. Loss of the biosynthetic enzyme NMNAT2, which converts nicotinamide mononucleotide (NMN) to NAD(+), activates SARM1 via an unknown me...

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Publicado no:Neuron
Main Authors: Figley, Matthew D., Gu, Weixi, Nanson, Jeffrey D., Shi, Yun, Sasaki, Yo, Cunnea, Katie, Malde, Alpeshkumar K., Jia, Xinying, Luo, Zhenyao, Saikot, Forhad K., Mosaiab, Tamim, Masic, Veronika, Holt, Stephanie, Hartley-Tassell, Lauren, McGuinness, Helen Y., Manik, Mohammad K., Bosanac, Todd, Landsberg, Michael J., Kerry, Philip S., Mobli, Mehdi, Hughes, Robert O., Milbrandt, Jeffrey, Kobe, Bostjan, DiAntonio, Aaron, Ve, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8174188/
https://ncbi.nlm.nih.gov/pubmed/33657413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2021.02.009
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