Polyamine Modulation of Anticonvulsant Drug Response: A Potential Mechanism Contributing to Pharmacoresistance in Chronic Epilepsy

Despite the development of numerous novel anticonvulsant drugs, ∼30% of epilepsy patients remain refractory to antiepileptic drugs (AEDs). Many established and novel AEDs reduce hyperexcitability via voltage- and use-dependent inhibition of voltage-gated Na(+) channels. For the widely used anticonvu...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Beckonert, Niklas Michael, Opitz, Thoralf, Pitsch, Julika, Soares da Silva, Patrício, Beck, Heinz
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2018
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8174136/
https://ncbi.nlm.nih.gov/pubmed/29789377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0640-18.2018
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