The heterogeneous human memory CCR6+ T helper-17 populations differ in T-bet and cytokine expression but all activate synovial fibroblasts in an IFNγ-independent manner

BACKGROUND: Chronic synovial inflammation is an important hallmark of inflammatory arthritis, but the cells and mechanisms involved are incompletely understood. Previously, we have shown that CCR6+ memory T-helper (memTh) cells and synovial fibroblasts (SF) activate each other in a pro-inflammatory...

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Publicado en:Arthritis Res Ther
Autores principales: Dankers, Wendy, den Braanker, Hannah, Paulissen, Sandra M. J., van Hamburg, Jan Piet, Davelaar, Nadine, Colin, Edgar M., Lubberts, Erik
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8173960/
https://ncbi.nlm.nih.gov/pubmed/34082814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-021-02532-9
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