Raised sputum extracellular DNA confers lung function impairment and poor symptom control in an exacerbation-susceptible phenotype of neutrophilic asthma

BACKGROUND: Extracellular DNA (e-DNA) and neutrophil extracellular traps (NETs) are linked to asthmatics airway inflammation. However, data demonstrating the characterization of airway inflammation associated with excessive e-DNA production and its impact on asthma outcomes are limited. OBJECTIVE: T...

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Publicat a:Respir Res
Autors principals: Abdo, Mustafa, Uddin, Mohib, Goldmann, Torsten, Marwitz, Sebastian, Bahmer, Thomas, Holz, Olaf, Kirsten, Anne-Marie, Trinkmann, Frederik, von Mutius, Erika, Kopp, Matthias, Hansen, Gesine, Rabe, Klaus F., Watz, Henrik, Pedersen, Frauke
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8173872/
https://ncbi.nlm.nih.gov/pubmed/34082773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-021-01759-z
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