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Cyclobutanone Inhibitor of Cobalt-Functionalized Metallo-γ-Lactonase AiiA with Cyclobutanone Ring Opening in the Active Site

[Image: see text] An α-amido cyclobutanone possessing a C10 hydrocarbon tail was designed as a potential transition-state mimetic for the quorum-quenching metallo-γ-lactonase autoinducer inactivator A (AiiA) with the support of in-house modeling techniques and found to be a competitive inhibitor of...

詳細記述

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書誌詳細
出版年:ACS Omega
主要な著者: Reidl, Cory T., Mascarenhas, Romila, Mohammad, Thahani S. Habeeb, Lutz, Marlon R., Thomas, Pei W., Fast, Walter, Liu, Dali, Becker, Daniel P.
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2021
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8173579/
https://ncbi.nlm.nih.gov/pubmed/34095651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.0c06348
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