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Insights into the substrate discrimination mechanisms of methyl-CpG-binding domain 4
G:T mismatches, the major mispairs generated during DNA metabolism, are repaired in part by mismatch-specific DNA glycosylases such as methyl-CpG-binding domain 4 (MBD4) and thymine DNA glycosylase (TDG). Mismatch-specific DNA glycosylases must discriminate the mismatches against million-fold excess...
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| Veröffentlicht in: | Biochem J |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8173489/ https://ncbi.nlm.nih.gov/pubmed/33960375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20210017 |
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