Ipomoeassin-F disrupts multiple aspects of secretory protein biogenesis

The Sec61 complex translocates nascent polypeptides into and across the membrane of the endoplasmic reticulum (ER), providing access to the secretory pathway. In this study, we show that Ipomoeassin-F (Ipom-F), a selective inhibitor of protein entry into the ER lumen, blocks the in vitro translocati...

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Udgivet i:Sci Rep
Main Authors: Roboti, Peristera, O’Keefe, Sarah, Duah, Kwabena B., Shi, Wei Q., High, Stephen
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8173012/
https://ncbi.nlm.nih.gov/pubmed/34079010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-91107-4
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