Pilot Clinical Trial of Perioperative Durvalumab and Tremelimumab in the Treatment of Resectable Colorectal Cancer Liver Metastases

PURPOSE: Despite the prognostic importance of immune infiltrate in colorectal cancer (CRC), immunotherapy has demonstrated limited clinical activity in refractory metastatic proficient mismatch repair (pMMR) CRC. This study explores combining anti-CTLA-4 and an anti-PDL-1 therapy in the preoperative...

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Pubblicato in:Clin Cancer Res
Autori principali: Marie, Preeti Kanikarla, Haymaker, Cara, Parra, Edwin Roger, Kim, Young Uk, Lazcano, Rossana, Gite, Swati, Lorenzini, Daniele, Wistuba, Ignacio I., Tidwell, Rebecca S Slack, Song, Xiaofei, Foo, Wai Chin, Maru, Dipen M, Chun, Yun Shin, Futreal, Andy, Kee, Bryan, Menter, David, Solis, Luisa, Tzeng, Ching-Wei, Parseghian, Christine, Raghav, Kanwal, Morris, Van, Chang, Chia-Chi, Jenq, Robert, Tam, Alda, Bernatchez, Chantale, Kopetz, Scott, Vauthey, Jean-Nicolas, Overman, Michael J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8172528/
https://ncbi.nlm.nih.gov/pubmed/33811152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-21-0163
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