Resistance to lethal ectromelia virus infection requires Type I interferon receptor in natural killer cells and monocytes but not in adaptive immune or parenchymal cells

Type I interferons (IFN-I) are antiviral cytokines that signal through the ubiquitous IFN-I receptor (IFNAR). Following footpad infection with ectromelia virus (ECTV), a mouse-specific pathogen, C57BL/6 (B6) mice survive without disease, while B6 mice broadly deficient in IFNAR succumb rapidly. We n...

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Udgivet i:PLoS Pathog
Main Authors: Melo-Silva, Carolina R., Alves-Peixoto, Pedro, Heath, Natasha, Tang, Lingjuan, Montoya, Brian, Knudson, Cory J., Stotesbury, Colby, Ferez, Maria, Wong, Eric, Sigal, Luis J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8172060/
https://ncbi.nlm.nih.gov/pubmed/34015056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009593
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