Potential for immune-driven viral polymorphisms to compromise antiretroviral-based preexposure prophylaxis for prevention of HIV-1 infection

OBJECTIVE: Long-acting rilpivirine is a candidate for preexposure prophylaxis (PrEP) for prevention of HIV-1 infection. However, rilpivirine resistance mutations at reverse transcriptase codon 138 (E138X) occur naturally in a minority of HIV-1-infected persons; in particular those expressing human l...

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Pubblicato in:AIDS
Autori principali: Gatanaga, Hiroyuki, Brumme, Zabrina L., Adland, Emily, Reyes-Terán, Gustavo, Avila-Rios, Santiago, Mejía-Villatoro, Carlos R., Hayashida, Tsunefusa, Chikata, Takayuki, Tran, Giang Van, Nguyen, Kinh Van, Meza, Rita I., Palou, Elsa Y., Valenzuela-Ponce, Humberto, Pascale, Juan M., Porras-Cortés, Guillermo, Manzanero, Marvin, Lee, Guinevere Q., Martin, Jeffrey N., Carrington, Mary N., John, Mina, Mallal, Simon, Poon, Art F.Y., Goulder, Philip, Takiguchi, Masafumi, Oka, Shinichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8171589/
https://ncbi.nlm.nih.gov/pubmed/28650381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000001575
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