HDAC1 Upregulation by NANOG Promotes Multidrug Resistance and a Stem-like Phenotype in Immune Edited Tumor Cells

Cancer immunoediting drives the adaptation of tumor cells to host immune surveillance. Immunoediting driven by antigen (Ag)-specific T cells enriches NANOG expression in tumor cells, resulting in a stem-like phenotype and immune resistance. Here, we identify HDAC1 as a key mediator of the NANOG-asso...

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Publicado no:Cancer Res
Main Authors: Song, Kwon-Ho, Choi, Chel Hun, Lee, Hyo-Jung, Oh, Se Jin, Woo, Seon Rang, Hong, Soon-Oh, Noh, Kyung Hee, Cho, Hanbyoul, Chung, Eun Joo, Kim, Jae-Hoon, Chung, Joon-Yong, Hewitt, Stephen M., Baek, Seungki, Lee, Kyung-Mi, Yee, Cassian, Son, Minjoo, Mao, Chih-Ping, Wu, T.C., Kim, Tae Woo
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8171587/
https://ncbi.nlm.nih.gov/pubmed/28716899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0072
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