Anomalous structural dynamics of minimally frustrated residues in cardiac troponin C triggers hypertrophic cardiomyopathy

Cardiac TnC (cTnC) is highly conserved among mammals, and genetic variants can result in disease by perturbing Ca(2+)-regulation of myocardial contraction. Here, we report the molecular basis of a human mutation in cTnC's αD-helix (TNNC1-p.C84Y) that impacts conformational dynamics of the D/E c...

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Vydáno v:Chem Sci
Hlavní autoři: Marques, Mayra A., Landim-Vieira, Maicon, Moraes, Adolfo H., Sun, Bin, Johnston, Jamie R., Dieseldorff Jones, Karissa M., Cino, Elio A., Parvatiyar, Michelle S., Valera, Isela C., Silva, Jerson L., Galkin, Vitold E., Chase, P. Bryant, Kekenes-Huskey, Peter M., de Oliveira, Guilherme A. P., Pinto, Jose Renato
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society of Chemistry 2021
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8171346/
https://ncbi.nlm.nih.gov/pubmed/34163821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1sc01886h
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