Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment

Background: Increased IL-6 level, M2 macrophages and PD-1(+)CD8(+) T cells in tumor microenvironments (TME) have been identified to correlate with resistance to checkpoint blockade immunotherapy, yet the mechanism remains poorly understood. Rab small GTPase-mediated trafficking of cytokines is criti...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Kuo, I-Ying, Yang, You-En, Yang, Pei-Shan, Tsai, Yu-Jou, Tzeng, Hong-Tai, Cheng, Hung-Chi, Kuo, Wan-Ting, Su, Wu-Chou, Chang, Chih-Peng, Wang, Yi-Ching
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2021
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8171097/
https://ncbi.nlm.nih.gov/pubmed/34093869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.60040
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