Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

BACKGROUND: Transferrin receptor (TfR1) mediated enhanced brain delivery of antibodies have been studied extensively in preclinical settings. However, the brain pharmacokinetics, i.e. brain entry, distribution and elimination are still not fully understood for this class of antibodies. The overall a...

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Detaylı Bibliyografya
Yayımlandı:Fluids Barriers CNS
Asıl Yazarlar: Faresjö, Rebecca, Bonvicini, Gillian, Fang, Xiaotian T., Aguilar, Ximena, Sehlin, Dag, Syvänen, Stina
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2021
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8170802/
https://ncbi.nlm.nih.gov/pubmed/34078410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12987-021-00257-0
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