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Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

BACKGROUND: Transferrin receptor (TfR1) mediated enhanced brain delivery of antibodies have been studied extensively in preclinical settings. However, the brain pharmacokinetics, i.e. brain entry, distribution and elimination are still not fully understood for this class of antibodies. The overall a...

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Detalhes bibliográficos
Publicado no:Fluids Barriers CNS
Main Authors: Faresjö, Rebecca, Bonvicini, Gillian, Fang, Xiaotian T., Aguilar, Ximena, Sehlin, Dag, Syvänen, Stina
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8170802/
https://ncbi.nlm.nih.gov/pubmed/34078410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12987-021-00257-0
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