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Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size
BACKGROUND: Transferrin receptor (TfR1) mediated enhanced brain delivery of antibodies have been studied extensively in preclinical settings. However, the brain pharmacokinetics, i.e. brain entry, distribution and elimination are still not fully understood for this class of antibodies. The overall a...
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| Publicat a: | Fluids Barriers CNS |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8170802/ https://ncbi.nlm.nih.gov/pubmed/34078410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12987-021-00257-0 |
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