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PS-341 alleviates chronic low-grade inflammation and improves insulin sensitivity through the inhibition of TM4 (UBAC2) degradation

BACKGROUND: The TM4 (UBAC2) protein, which contains 4 transmembrane domains and one ubiquitin binding domain, is mainly expressed in cell and nuclear membranes. The current research aimed to explore the role of TM4 in metabolic inflammation and to examine whether the ubiquitin–proteasome inhibitor P...

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Detalhes bibliográficos
Publicado no:Nutr Metab (Lond)
Main Authors: Chen, Lili, Ye, Kuanping, Feng, Xiaocheng, Li, Lianxi, Li, Qin, Huang, Ying, Wang, Xuanchun, Li, Rumei, Hu, Cheng, Yang, Zhen, Lu, Bin, Yang, Yehong, Wen, Jie, Zhang, Zhaoyun, He, Min, Wang, Qinghua, Zhou, Wenbai, Li, Yintao, Liu, Naijia, Huang, Jinya, Shen, Qiwei, Yao, Qiyuan, Hu, Renming
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8170790/
https://ncbi.nlm.nih.gov/pubmed/34074311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12986-021-00579-8
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