PS-341 alleviates chronic low-grade inflammation and improves insulin sensitivity through the inhibition of TM4 (UBAC2) degradation

BACKGROUND: The TM4 (UBAC2) protein, which contains 4 transmembrane domains and one ubiquitin binding domain, is mainly expressed in cell and nuclear membranes. The current research aimed to explore the role of TM4 in metabolic inflammation and to examine whether the ubiquitin–proteasome inhibitor P...

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Veröffentlicht in:Nutr Metab (Lond)
Hauptverfasser: Chen, Lili, Ye, Kuanping, Feng, Xiaocheng, Li, Lianxi, Li, Qin, Huang, Ying, Wang, Xuanchun, Li, Rumei, Hu, Cheng, Yang, Zhen, Lu, Bin, Yang, Yehong, Wen, Jie, Zhang, Zhaoyun, He, Min, Wang, Qinghua, Zhou, Wenbai, Li, Yintao, Liu, Naijia, Huang, Jinya, Shen, Qiwei, Yao, Qiyuan, Hu, Renming
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2021
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8170790/
https://ncbi.nlm.nih.gov/pubmed/34074311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12986-021-00579-8
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