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Protofilament structure and supramolecular polymorphism of aggregated mutant huntingtin exon 1
Huntington’s disease is a progressive neurodegenerative disease caused by expansion of the polyglutamine domain in the first exon of huntingtin (HttEx1). The extent of expansion correlates with disease progression and formation of amyloid-like protein deposits within the brain. The latter display po...
Guardat en:
| Publicat a: | J Mol Biol |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8170701/ https://ncbi.nlm.nih.gov/pubmed/32598938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2020.06.021 |
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