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Protofilament structure and supramolecular polymorphism of aggregated mutant huntingtin exon 1

Huntington’s disease is a progressive neurodegenerative disease caused by expansion of the polyglutamine domain in the first exon of huntingtin (HttEx1). The extent of expansion correlates with disease progression and formation of amyloid-like protein deposits within the brain. The latter display po...

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Publicat a:J Mol Biol
Autors principals: Boatz, Jennifer C., Piretra, Talia, Lasorsa, Alessia, Matlahov, Irina, Conway, James F., van der Wel, Patrick C. A.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8170701/
https://ncbi.nlm.nih.gov/pubmed/32598938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2020.06.021
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