Rational Design of Right-Handed Heterogeneous Peptidomimetics as Inhibitors of Protein–Protein Interactions

Peptidomimetics have gained great attention for their function as protein–protein interaction (PPI) inhibitors. Herein, we report the design and investigation of a series of right-handed helical heterogeneous 1:1 α/Sulfono-γ-AA peptides as unprecedented inhibitors for p53-MDM2 and p53-MDMX. The most...

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Bibliographic Details
Published in:J Med Chem
Main Authors: Shi, Yan, Sang, Peng, Lu, Junhao, Higbee, Pirada, Chen, Lihong, Yang, Leixiang, Odom, Timothy, Daughdrill, Gary, Chen, Jiandong, Cai, Jianfeng
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8170677/
https://ncbi.nlm.nih.gov/pubmed/33140956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01638
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