Spontaneous mouse lymphoma in patient-derived tumor xenografts: The importance of systematic analysis of xenografted human tumor tissues in preclinical efficacy trials

Patient-derived tumor xenograft (PDX) is now largely recognized as a key preclinical model for cancer research, mimicking patient tumor phenotype and genotype. Immunodeficient mice, well-known to develop spontaneous lymphoma, are required for PDX growth. As for all animal models used for further cli...

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Detalhes bibliográficos
Publicado no:Transl Oncol
Main Authors: Chateau-Joubert, Sophie, Hopfe, Miriam, Richon, Sophie, Decaudin, Didier, Roman-Roman, Sergio, Reyes-Gomez, Edouard, Bieche, Ivan, Nemati, Fariba, Dangles-Marie, Virginie
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2021
Assuntos:
Perspective
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8170170/
https://ncbi.nlm.nih.gov/pubmed/34051622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2021.101133
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