Kinetics of Abacavir-Induced Remodelling of the Major Histocompatibility Complex Class I Peptide Repertoire

Abacavir hypersensitivity syndrome can occur in individuals expressing the HLA-B*57:01 major histocompatibility complex class I allotype when utilising the drug abacavir as a part of their anti-retroviral regimen. The drug is known to bind within the HLA-B*57:01 antigen binding cleft, leading to the...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Illing, Patricia T., van Hateren, Andy, Darley, Rachel, Croft, Nathan P., Mifsud, Nicole A., King, Samuel, Kostenko, Lyudmila, Bharadwaj, Mandvi, McCluskey, James, Elliott, Tim, Purcell, Anthony W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8170132/
https://ncbi.nlm.nih.gov/pubmed/34093574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.672737
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