Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma

Glioblastoma (GBM) is an incurable and highly heterogeneous brain tumor, originating from human neural stem/progenitor cells (hNSCs/hNPCs) years ahead of diagnosis. Despite extensive efforts to characterize hNSCs and end-stage GBM at bulk and single-cell levels, the de novo gliomagenic path from hNS...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Wang, Xiaofei, Zhou, Ran, Xiong, Yanzhen, Zhou, Lingling, Yan, Xiang, Wang, Manli, Li, Fan, Xie, Chuanxing, Zhang, Yiming, Huang, Zongyao, Ding, Chaoqiong, Shi, Kaidou, Li, Weida, Liu, Yu, Cao, Zhongwei, Zhang, Zhen-Ning, Zhou, Shengtao, Chen, Chong, Zhang, Yan, Chen, Lu, Wang, Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Singapore 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8169837/
https://ncbi.nlm.nih.gov/pubmed/33390587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-020-00451-z
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