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Mechanisms of typhoid toxin neutralization by antibodies targeting glycan receptor binding and nuclease subunits

Nearly all clinical isolates of Salmonella Typhi, the cause of typhoid fever, are antibiotic resistant. All S. Typhi isolates secrete an A(2)B(5) exotoxin called typhoid toxin to benefit the pathogen during infection. Here, we demonstrate that antibiotic-resistant S. Typhi secretes typhoid toxin con...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Ahn, Changhwan, Yang, Yi-An, Neupane, Durga P., Nguyen, Tri, Richards, Angelene F., Sim, Ji Hyun, Mantis, Nicholas J., Song, Jeongmin
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8169802/
https://ncbi.nlm.nih.gov/pubmed/34113815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102454
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