Copper-catalyzed carbo-difluoromethylation of alkenes via radical relay

Organic molecules that contain alkyl-difluoromethyl moieties have received increased attention in medicinal chemistry, but their synthesis in a modular and late-stage fashion remains challenging. We report herein an efficient copper-catalyzed radical relay approach for the carbo-difluoromethylation...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Cai, Aijie, Yan, Wenhao, Zeng, Xiaojun, Zacate, Samson B., Chao, Tzu-Hsuan, Krause, Jeanette A., Cheng, Mu-Jeng, Liu, Wei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8169770/
https://ncbi.nlm.nih.gov/pubmed/34075051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23590-2
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