The ER chaperones BiP and Grp94 regulate the formation of insulin-like growth factor 2 (IGF2) oligomers.

While cytosolic Hsp90 chaperones have been extensively studied, less is known about how the ER Hsp90 paralog Grp94 recognizes clients and influences client folding. Here, we examine how Grp94 and the ER Hsp70 paralog, BiP, influence the folding of insulin-like growth factor 2 (IGF2), an established...

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Publicado en:J Mol Biol
Main Authors: Jin, Yi, Kotler, Judy L.M., Wang, Shiyu, Huang, Bin, Halpin, Jackson C., Street, Timothy O.
Formato: Artigo
Idioma:Inglês
Publicado: 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8169611/
https://ncbi.nlm.nih.gov/pubmed/33811917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2021.166963
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