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The Colonic Mucosal MicroRNAs, MicroRNA-219a-5p, and MicroRNA-338-3p Are Downregulated in Irritable Bowel Syndrome and Are Associated With Barrier Function and Mitogen-Activated Protein Kinase (MAPK) Signaling

BACKGROUND AND AIMS: Alterations in microRNA (miRNA) and in the intestinal barrier are putative risk factors for irritable bowel syndrome (IBS). We aimed to identify differentially expressed colonic mucosal miRNAs, their targets in IBS compared to healthy controls (HCs), and putative downstream path...

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Detalhes bibliográficos
Publicado no:Gastroenterology
Main Authors: Mahurkar-Joshi, Swapna, Rankin, Carl Robert, Videlock, Elizabeth Jane, Soroosh, Artin, Verma, Abhishek, Khandadash, Ariela, Iliopoulos, Dimitrios, Pothoulakis, Charalabos, Mayer, Emeran A, Chang, Lin
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8169529/
https://ncbi.nlm.nih.gov/pubmed/33617890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2021.02.040
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