Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses

Members of the SH3- and ankyrin repeat (SHANK) protein family are considered as master scaffolds of the postsynaptic density of glutamatergic synapses. Several missense mutations within the canonical SHANK3 isoform have been proposed as causative for the development of autism spectrum disorders (ASD...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Bucher, Michael, Niebling, Stephan, Han, Yuhao, Molodenskiy, Dmitry, Hassani Nia, Fatemeh, Kreienkamp, Hans-Jürgen, Svergun, Dmitri, Kim, Eunjoon, Kostyukova, Alla S, Kreutz, Michael R, Mikhaylova, Marina
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2021
Assuntos:
Neuroscience
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8169116/
https://ncbi.nlm.nih.gov/pubmed/33945465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.66165
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