Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses

Members of the SH3- and ankyrin repeat (SHANK) protein family are considered as master scaffolds of the postsynaptic density of glutamatergic synapses. Several missense mutations within the canonical SHANK3 isoform have been proposed as causative for the development of autism spectrum disorders (ASD...

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Опубликовано в: :eLife
Главные авторы: Bucher, Michael, Niebling, Stephan, Han, Yuhao, Molodenskiy, Dmitry, Hassani Nia, Fatemeh, Kreienkamp, Hans-Jürgen, Svergun, Dmitri, Kim, Eunjoon, Kostyukova, Alla S, Kreutz, Michael R, Mikhaylova, Marina
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2021
Предметы:
Neuroscience
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8169116/
https://ncbi.nlm.nih.gov/pubmed/33945465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.66165
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