Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses

Members of the SH3- and ankyrin repeat (SHANK) protein family are considered as master scaffolds of the postsynaptic density of glutamatergic synapses. Several missense mutations within the canonical SHANK3 isoform have been proposed as causative for the development of autism spectrum disorders (ASD...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Bucher, Michael, Niebling, Stephan, Han, Yuhao, Molodenskiy, Dmitry, Hassani Nia, Fatemeh, Kreienkamp, Hans-Jürgen, Svergun, Dmitri, Kim, Eunjoon, Kostyukova, Alla S, Kreutz, Michael R, Mikhaylova, Marina
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2021
Onderwerpen:
Neuroscience
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8169116/
https://ncbi.nlm.nih.gov/pubmed/33945465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.66165
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