Systematic screening of viral and human genetic variation identifies antiretroviral resistance and immune escape link

BACKGROUND: Considering the remaining threat of drug-resistantmutations (DRMs) to antiretroviral treatment (ART) efficacy, we investigated how the selective pressure of human leukocyte antigen (HLA)-restricted cytotoxic T lymphocytes drives certain DRMs’ emergence and retention. METHODS: We systemat...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Nguyen, Huyen, Thorball, Christian Wandell, Fellay, Jacques, Böni, Jürg, Yerly, Sabine, Perreau, Matthieu, Hirsch, Hans H, Kusejko, Katharina, Thurnheer, Maria Christine, Battegay, Manuel, Cavassini, Matthias, Kahlert, Christian R, Bernasconi, Enos, Günthard, Huldrych F, Kouyos, Roger D
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Epidemiology and Global Health
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8169104/
https://ncbi.nlm.nih.gov/pubmed/34061023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.67388
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