Systematic screening of viral and human genetic variation identifies antiretroviral resistance and immune escape link

BACKGROUND: Considering the remaining threat of drug-resistantmutations (DRMs) to antiretroviral treatment (ART) efficacy, we investigated how the selective pressure of human leukocyte antigen (HLA)-restricted cytotoxic T lymphocytes drives certain DRMs’ emergence and retention. METHODS: We systemat...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Nguyen, Huyen, Thorball, Christian Wandell, Fellay, Jacques, Böni, Jürg, Yerly, Sabine, Perreau, Matthieu, Hirsch, Hans H, Kusejko, Katharina, Thurnheer, Maria Christine, Battegay, Manuel, Cavassini, Matthias, Kahlert, Christian R, Bernasconi, Enos, Günthard, Huldrych F, Kouyos, Roger D
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2021
Teme:
Epidemiology and Global Health
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8169104/
https://ncbi.nlm.nih.gov/pubmed/34061023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.67388
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