Systematic screening of viral and human genetic variation identifies antiretroviral resistance and immune escape link

BACKGROUND: Considering the remaining threat of drug-resistantmutations (DRMs) to antiretroviral treatment (ART) efficacy, we investigated how the selective pressure of human leukocyte antigen (HLA)-restricted cytotoxic T lymphocytes drives certain DRMs’ emergence and retention. METHODS: We systemat...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Nguyen, Huyen, Thorball, Christian Wandell, Fellay, Jacques, Böni, Jürg, Yerly, Sabine, Perreau, Matthieu, Hirsch, Hans H, Kusejko, Katharina, Thurnheer, Maria Christine, Battegay, Manuel, Cavassini, Matthias, Kahlert, Christian R, Bernasconi, Enos, Günthard, Huldrych F, Kouyos, Roger D
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2021
Pynciau:
Epidemiology and Global Health
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8169104/
https://ncbi.nlm.nih.gov/pubmed/34061023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.67388
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