iPSC Modeling of RBM20-Deficient DCM Identifies Upregulation of RBM20 as a Therapeutic Strategy

Recent advances in induced pluripotent stem cell (iPSC) technology and directed differentiation of iPSCs into cardiomyocytes (iPSC-CMs) make it possible to model genetic heart disease in vitro. We apply CRISPR/Cas9 genome editing technology to introduce three RBM20 mutations in iPSCs and differentia...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Briganti, Francesca, Sun, Han, Wei, Wu, Wu, Jingyan, Zhu, Chenchen, Liss, Martin, Karakikes, Ioannis, Rego, Shannon, Cipriano, Andrea, Snyder, Michael, Meder, Benjamin, Xu, Zhenyu, Millat, Gilles, Gotthardt, Michael, Mercola, Mark, Steinmetz, Lars M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168789/
https://ncbi.nlm.nih.gov/pubmed/32905764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108117
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