CD40 Activity on Mesenchymal Cells Negatively Regulates OX40L to Maintain Bone Marrow Immune Homeostasis Under Stress Conditions

BACKGROUND: Within the bone marrow (BM), mature T cells are maintained under homeostatic conditions to facilitate proper hematopoietic development. This homeostasis depends upon a peculiar elevated frequency of regulatory T cells (Tregs) and immune regulatory activities from BM-mesenchymal stem cell...

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Vydáno v:Front Immunol
Hlavní autoři: Bassani, Barbara, Tripodo, Claudio, Portararo, Paola, Gulino, Alessandro, Botti, Laura, Chiodoni, Claudia, Jachetti, Elena, Bolli, Niccolò, Ciciarello, Marilena, Joehrens, Korinna, Anagnostopoulos, Ioannis, Na, Il-Kang, Curti, Antonio, Colombo, Mario P., Sangaletti, Sabina
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168593/
https://ncbi.nlm.nih.gov/pubmed/34084166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.662048
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