Prognostic significance of translocations in the presence of mutated IGHV and of cytogenetic complexity at diagnosis of chronic lymphocytic leukemia

Mutations of the IGH variable region in patients with chronic lymphocytic leukemia are associated with a favorable prognosis, whereas cytogenetic complexity (≥3 unrelated aberrations) and translocations have been associated with an unfavorable prognosis. While mutational status of IGHV is stable, cy...

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Publicado en:Haematologica
Autores principales: Heerema, Nyla A., Muthusamy, Natarajan, Zhao, Qiuhong, Ruppert, Amy S., Breidenbach, Heather, Andritsos, Leslie A., Grever, Michael R., Maddocks, Kami J., Woyach, Jennifer, Awan, Farrukh, Long, Meixiao, Gordon, Amber, Coombes, Caitlin, Byrd, John C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Fondazione Ferrata Storti 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168513/
https://ncbi.nlm.nih.gov/pubmed/32414849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.212571
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