Prognostic significance of translocations in the presence of mutated IGHV and of cytogenetic complexity at diagnosis of chronic lymphocytic leukemia

Mutations of the IGH variable region in patients with chronic lymphocytic leukemia are associated with a favorable prognosis, whereas cytogenetic complexity (≥3 unrelated aberrations) and translocations have been associated with an unfavorable prognosis. While mutational status of IGHV is stable, cy...

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Bibliographic Details
Published in:Haematologica
Main Authors: Heerema, Nyla A., Muthusamy, Natarajan, Zhao, Qiuhong, Ruppert, Amy S., Breidenbach, Heather, Andritsos, Leslie A., Grever, Michael R., Maddocks, Kami J., Woyach, Jennifer, Awan, Farrukh, Long, Meixiao, Gordon, Amber, Coombes, Caitlin, Byrd, John C.
Format: Artigo
Language:Inglês
Published: Fondazione Ferrata Storti 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168513/
https://ncbi.nlm.nih.gov/pubmed/32414849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.212571
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