Reduction of endotoxicity in Bordetella bronchiseptica by lipid A engineering: Characterization of lpxL1 and pagP mutants

Whole-cell vaccines against Gram-negative bacteria commonly display high reactogenicity caused by the endotoxic activity of lipopolysaccharide (LPS), one of the major components of the bacterial outer membrane. Underacylation of the lipid A moiety of LPS has been related with reduced endotoxicity in...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Virulence
Päätekijät: Pérez-Ortega, Jesús, Van Harten, Roel M., Van Boxtel, Ria, Plisnier, Michel, Louckx, Marc, Ingels, Dominique, Haagsman, Henk P., Tommassen, Jan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Taylor & Francis 2021
Aiheet:
Research Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168481/
https://ncbi.nlm.nih.gov/pubmed/34053396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21505594.2021.1929037
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