Oncolytic Adenovirus Coding for a Variant Interleukin 2 (vIL-2) Cytokine Re-Programs the Tumor Microenvironment and Confers Enhanced Tumor Control

The notion of developing variants of the classic interleukin 2 (IL-2) cytokine has emerged from the limitations observed with the systemic use of human IL-2 in the clinic: severe adverse events accompanied by low therapeutic response rate in treated patients. Modifications made in the IL-2 receptor-...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Quixabeira, Dafne C. A., Zafar, Sadia, Santos, Joao M., Cervera-Carrascon, Victor, Havunen, Riikka, Kudling, Tatiana V., Basnet, Saru, Anttila, Marjukka, Kanerva, Anna, Hemminki, Akseli
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168464/
https://ncbi.nlm.nih.gov/pubmed/34084172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.674400
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