Adenovirus Coding for Interleukin-2 and Tumor Necrosis Factor Alpha Replaces Lymphodepleting Chemotherapy in Adoptive T Cell Therapy

Lymphodepleting preconditioning with high-dose chemotherapy is commonly used to increase the clinical efficacy of adoptive T cell therapy (ACT) strategies, however, with severe toxicity for patients. Conversely, oncolytic adenoviruses are safe and, when engineered to express interleukin-2 (IL-2) and...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Ther
Hauptverfasser: Santos, João Manuel, Cervera-Carrascon, Víctor, Havunen, Riikka, Zafar, Sadia, Siurala, Mikko, Sorsa, Suvi, Anttila, Marjukka, Kanerva, Anna, Hemminki, Akseli
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2018
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6127851/
https://ncbi.nlm.nih.gov/pubmed/30017877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.06.001
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