TMOD-06. LOSS OF DICER COOPERATES WITH TUMOR SUPPRESSORS TO INITIATE METASTATIC MEDULLOBLASTOMA

To determine the role of microRNA regulation in brain tumor development, we incorporated a conditional allele of the microRNA processing enzyme Dicer to a previously characterized glioma mouse model based on inactivation of the tumor suppressors Nf1, Trp53, and Pten using the Nestin-creER(T2) transg...

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Vydáno v:Neuro Oncol
Hlavní autoři: Alcantara Llaguno, Sheila, Nazarenko, Inga, Chen, Yuntao, Sun, Daochun, Rocca, Gaspare La, Pedraza, Alicia, Gudenas, Brian, Saulnier, Olivier, Burns, Dennis, Bale, Tejus, Northcott, Paul, Taylor, Michael, Ventura, Andrea, Parada, Luis
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
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Models
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168245/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.147
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