EPEN-07. SINGLE-CELL RNA SEQUENCING IDENTIFIES A UNIQUE MYELOID SUBPOPULATION ASSOCIATED WITH MESENCHYMAL TUMOR SUBPOPULATION IN POOR OUTCOME PEDIATRIC EPENDYMOMA

We have previously shown immune gene phenotype variations between posterior fossa ependymoma subgroups. PFA1 tumors chronically secrete IL-6, which induces secretion of myeloid cell IL-8 and pushes the infiltrating myeloid cells to an immune suppressive function. In contrast, PFA2 tumors have a more...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Griesinger, Andrea, Riemondy, Kent, Donson, Andrew, Willard, Nicholas, Prince, Eric, Harris, Faith, Amani, Vladimir, Grimaldo, Enrique, Hankinson, Todd, Grundy, Richard, Jackson, Andrew, Foreman, Nicholas, Ritzmann, Timothy
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2021
Fag:
Ependymoma
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168243/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.057
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