RARE-18. NF1-MUTATED TUMORS EXHIBIT INCREASED SENSITIVITY TO AUTOPHAGY INHIBITION ALONE AND IN COMBINATION WITH MEK INHIBITION

BACKGROUND: Autophagy inhibition is a potential treatment for central nervous system (CNS) tumors. Autophagy, a heavily regulated process by which cellular waste is transferred to lysosomes for degradation and processing, is an integral part of tumor cell survival under stressful conditions includin...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Baird-Daniel, Eliza, Zahedi, Shadi, Morin, Andrew, Desmarais, Michelle, Williams, Kyle, Williams, Rory, Vibhakar, Rajeev, Foreman, Nicholas, Mulcahy-Levy, Jean
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2021
Soggetti:
Rare Tumors/Other
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168095/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.179
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