HGG-38. DE NOVO PYRIMIDINE SYNTHESIS INHIBITION INDUCES REPLICATION CATASTROPHE MEDIATED CELL DEATH IN DIFFUSE MIDLINE GLIOMA

Diffuse midline gliomas (DMG) are aggressive and lethal pediatric brain tumors that cannot be cured by conventional therapeutic modalities. Using a genome wide CRISPR screen we identified the de novo pyrimidine biosynthesis pathway as a metaboilic vulnerability in DMGs. BAY2402234 is a small molecul...

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Publicat a:Neuro Oncol
Autors principals: Pal, Sharmistha, Kaplan, Jakub, Stopka, Sylwia, Regan, Michael, Kann, Benjamin, Agar, Nathalie, Stiles, Charles, Cooney, Tabitha, Mueller, Sabine, Chowdhury, Dipanjan, Haas-Kogan, Daphne
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2021
Matèries:
High Grade Gliomas
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168089/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.102
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