HGG-38. DE NOVO PYRIMIDINE SYNTHESIS INHIBITION INDUCES REPLICATION CATASTROPHE MEDIATED CELL DEATH IN DIFFUSE MIDLINE GLIOMA

Diffuse midline gliomas (DMG) are aggressive and lethal pediatric brain tumors that cannot be cured by conventional therapeutic modalities. Using a genome wide CRISPR screen we identified the de novo pyrimidine biosynthesis pathway as a metaboilic vulnerability in DMGs. BAY2402234 is a small molecul...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Pal, Sharmistha, Kaplan, Jakub, Stopka, Sylwia, Regan, Michael, Kann, Benjamin, Agar, Nathalie, Stiles, Charles, Cooney, Tabitha, Mueller, Sabine, Chowdhury, Dipanjan, Haas-Kogan, Daphne
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2021
Fag:
High Grade Gliomas
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168089/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.102
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