HGG-38. DE NOVO PYRIMIDINE SYNTHESIS INHIBITION INDUCES REPLICATION CATASTROPHE MEDIATED CELL DEATH IN DIFFUSE MIDLINE GLIOMA

Diffuse midline gliomas (DMG) are aggressive and lethal pediatric brain tumors that cannot be cured by conventional therapeutic modalities. Using a genome wide CRISPR screen we identified the de novo pyrimidine biosynthesis pathway as a metaboilic vulnerability in DMGs. BAY2402234 is a small molecul...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Pal, Sharmistha, Kaplan, Jakub, Stopka, Sylwia, Regan, Michael, Kann, Benjamin, Agar, Nathalie, Stiles, Charles, Cooney, Tabitha, Mueller, Sabine, Chowdhury, Dipanjan, Haas-Kogan, Daphne
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
High Grade Gliomas
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168089/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.102
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