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E3 ubiquitin ligase von Hippel-Lindau (VHL) protein promotes Th17 differentiation
VHL is an E3 ubiquitin ligase that targets proteins, including HIF-1α, for proteasomal degradation. VHL and HIF regulate the balance between glycolysis and oxidative phosphorylation, which is critical in highly dynamic T cells. HIF-1α positively regulates Th17 differentiation, a complex process in w...
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| Vydáno v: | J Immunol |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8167928/ https://ncbi.nlm.nih.gov/pubmed/32690659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000243 |
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