Combining Mass Spectrometry-Based Phosphoproteomics with a Network-Based Approach to Reveal FLT3-Dependent Mechanisms of Chemoresistance

FLT3 mutations are the most frequently identified genetic alterations in acute myeloid leukemia (AML) and are associated with poor clinical outcome, relapse and chemotherapeutic resistance. Elucidating the molecular mechanisms underlying FLT3-dependent pathogenesis and drug resistance is a crucial g...

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Dettagli Bibliografici
Pubblicato in:Proteomes
Autori principali: Pugliese, Giusj Monia, Latini, Sara, Massacci, Giorgia, Perfetto, Livia, Sacco, Francesca
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
Soggetti:
Review
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8167576/
https://ncbi.nlm.nih.gov/pubmed/33925552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/proteomes9020019
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