Co-Transmission of Alpha-Synuclein and TPPP/p25 Inhibits Their Proteolytic Degradation in Human Cell Models

The pathological association of alpha-synuclein (SYN) and Tubulin Polymerization Promoting Protein (TPPP/p25) is a key factor in the etiology of synucleinopathies. In normal brains, the intrinsically disordered SYN and TPPP/p25 are not found together but exist separately in neurons and oligodendrocy...

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Vydáno v:Front Mol Biosci
Hlavní autoři: Lehotzky, Attila, Oláh, Judit, Fekete, János Tibor, Szénási, Tibor, Szabó, Edit, Győrffy, Balázs, Várady, György, Ovádi, Judit
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Molecular Biosciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8167055/
https://ncbi.nlm.nih.gov/pubmed/34084775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2021.666026
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