Aberrant transcriptional and post-transcriptional regulation of SPAG5, a YAP-TAZ-TEAD downstream effector, fuels breast cancer cell proliferation

Sperm-associated antigen 5 (SPAG5) is an important driver of the cell mitotic spindle required for chromosome segregation and progression into anaphase. SPAG5 has been identified as an important proliferation marker and chemotherapy-sensitivity predictor, especially in estrogen receptor-negative bre...

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Udgivet i:Cell Death Differ
Main Authors: Canu, Valeria, Donzelli, Sara, Sacconi, Andrea, Lo Sardo, Federica, Pulito, Claudio, Bossel, Noa, Di Benedetto, Anna, Muti, Paola, Botti, Claudio, Domany, Eytan, Bicciato, Silvio, Strano, Sabrina, Yarden, Yosef, Blandino, Giovanni
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8166963/
https://ncbi.nlm.nih.gov/pubmed/33230261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00677-9
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